Article

Genome-Encoded Cytoplasmic Double-Stranded RNAs, Found in C9ORF72 ALS-FTD Brain, Provoke Propagated Neuronal Death

2018-01-19

Abstract excerpt

<h4>SUMMARY</h4> Innate immune signaling activation and DNA damage are pathological hallmarks of aging that may herald multiple adult-onset neurodegenerative diseases. Here, we report that both cell autonomous and non-autonomous neuronal death are triggered by the production of cytoplasmic double-stranded RNA (cdsRNA) from a regulated, disarticulated transgene in the setting of type I interferon (IFN-I) signaling...

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Literature Corpus work: b7cc6d48-ef9c-5c8a-887a-dc5e76b08b89
DOI: 10.1101/248328

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