Article

Nucleolar stress generates ribosomal DNA–derived RNA–DNA hybrids that prime innate immunity

2025-10-16

Abstract excerpt

<title>Abstract</title> <p>Self- and non-self-nucleic acids are recognized by the innate immune system. Although RNA-DNA hybrids generated through R-loop formation during transcriptional stress have been implicated in innate immune activation, their physiological significance remains incompletely understood. Here, we demonstrate that nucleolar stress caused by dysfunction of nucleolar proteins RRN3 and ribosomal...

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Literature Corpus work: f4069ae5-d836-58fd-994f-7865a8bee5e4
DOI: 10.21203/rs.3.rs-7795572/v1

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