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Article

Telomeres in ICF syndrome cells are vulnerable to DNA damage due to elevated DNA:RNA hybrids

24 Jan 2017

Abstract excerpt

DNA:RNA hybrids, nucleic acid structures with diverse physiological functions, can disrupt genome integrity when dysregulated. Human telomeres were shown to form hybrids with the lncRNA TERRA, yet the formation and distribution of these hybrids among telomeres, their regulation and their cellular effects remain elusive. Here we predict and confirm in several human cell types that DNA:RNA hybrids form at many...

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PMID: 28117327
DOI: 10.1038/ncomms14015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Telomeres in ICF syndrome cells are vulnerable to DNA damage due to elevated DNA:RNA hybridsPMID 28117327Read ↗

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