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Article

Emerging role of RNA•DNA hybrids inC9orf72-linked neurodegeneration

16 Feb 2015

Abstract excerpt

RNA plays an active role in structural polymorphism of the genome through the formation of stable RNA•DNA hybrids (R-loops). R-loops can modulate normal physiological processes and are also associated with pathological conditions, such as those related to nucleotide repeat expansions. A guanine-rich hexanucleotide repeat expansion in chromosome 9 open reading frame 72 (C9orf72) has been linked to a spectrum of...

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PMID: 25590632
DOI: 10.1080/15384101.2014.995490

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