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Article

FairPRS: adjusting for admixed populations in polygenic risk scores using invariant risk minimization.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing - 1 Jan 2023

Machado Reyes Diego, Bose Aritra, Karavani Ehud, Parida Laxmi

Abstract excerpt

Polygenic risk scores (PRS) are increasingly used to estimate the personal risk of a trait based on genetics. However, most genomic cohorts are of European populations, with a strong under-representation of non-European groups. Given that PRS poorly transport across racial groups, this has the potential to exacerbate health disparities if used in clinical care. Hence there is a need to generate PRS that perform...

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PMID: 36540977
PMCID: PMC10804441

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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