Article

Modelling ferroptosis in a human microglial line by sequential exposure to iron and GPX4 inhibition

2026-01-21

Abstract excerpt

Excessive iron accumulation is a pathological feature of several neurodegenerative diseases (NDDs) and a growing body of evidence suggests that ferroptosis, an iron-dependent form of regulated cell death (RCD) driven by lipid peroxidation, is implicated in their pathogenesis. Microglia, the brain’s resident immune cells, buffer iron overload but become susceptible to ferroptotic death, exacerbating neuroinflammati...

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Literature Corpus work: 34842487-abb8-587d-b35c-e8a081147dcd
DOI: 10.64898/2026.01.19.700282

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