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Article

Pif1 family helicases promote mutation avoidance during DNA replication.

Nucleic acids research - 9 Dec 2022

Zhou Zhi-Xiong, Follonier Cindy, Lujan Scott A, Burkholder Adam B, Zakian Virginia A, Kunkel Thomas A

Abstract excerpt

Pif1 family 5' → 3' DNA helicases are important for replication fork progression and genome stability. The budding yeast Saccharomyces cerevisiae encodes two Pif1 family helicases, Rrm3 and Pif1, both of which are multi-functional. Here we describe novel functions for Rrm3 in promoting mutation avoidance during DNA replication. We show that loss of RRM3 results in elevated spontaneous mutations made by DNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36533450
DOI: 10.1093/nar/gkac1127
PMCID: PMC9825187

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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