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Article

DNA mutagenesis driven by transcription factor competition with mismatch repair.

Cell - 2 Oct 2025

Zhu Wei, Zhang Yuning, Sahay Harshit, Wasserman Hana, Afek Ariel, Williams Jonathan, Shaltz Samantha, Johnson Caitlin, Pinheiro Kyle, MacAlpine David M, Weninger Keith R, Erie Dorothy A, Jinks-Robertson Sue, Gordân Raluca

Abstract excerpt

Despite the remarkable fidelity of eukaryotic DNA replication, nucleotide misincorporation errors occur in every replication cycle, generating mutations that drive genetic diseases and genome evolution. Here, we show that transcription factor (TF) proteins, key players in gene regulation, can increase mutagenesis from replication errors by directly competing with the recognition of DNA mismatches by MutSα, the...

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Identifiers

PMID: 40738104
DOI: 10.1016/j.cell.2025.07.003
PMCID: PMC12327807

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TF
MYC

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