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Article

Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy.

DNA repair - 1 Aug 2017

Barbari Stephanie R, Shcherbakova Polina V

Abstract excerpt

The fidelity of DNA replication relies on three error avoidance mechanisms acting in series: nucleotide selectivity of replicative DNA polymerases, exonucleolytic proofreading, and post-replicative DNA mismatch repair (MMR). MMR defects are well known to be associated with increased cancer incidence. Due to advances in DNA sequencing technologies, the past several years have witnessed a long-predicted discovery...

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Identifiers

PMID: 28687338
DOI: 10.1016/j.dnarep.2017.06.003
PMCID: PMC5750057

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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