Article

MutLα suppresses error-prone DNA mismatch repair and preferentially protects noncoding DNA from mutations

2024-04-02

Abstract excerpt

<h4>ABSTRACT</h4> The DNA mismatch repair (MMR) system promotes genome stability and protects humans from certain types of cancer. Its primary function is the correction of DNA polymerase errors. MutLα is an important eukaryotic MMR factor. We have examined the contributions of MutLα to maintaining genome stability. We show here that loss of MutLα in yeast increases the genome-wide mutation rate by ∼130-fold and...

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Literature Corpus work: 9f263ffa-c67c-59ce-b3f2-0164022aa7a4
DOI: 10.1101/2024.04.01.587563

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