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Article

Genome-wide model for the normal eukaryotic DNA replication fork.

Proceedings of the National Academy of Sciences of the United States of America - 12 Oct 2010

Larrea Andres A, Lujan Scott A, Nick McElhinny Stephanie A, Mieczkowski Piotr A, Resnick Michael A, Gordenin Dmitry A, Kunkel Thomas A

Abstract excerpt

To investigate DNA replication enzymology across the nuclear genome of budding yeast, deep sequencing was used to establish the pattern of uncorrected replication errors generated by an asymmetric mutator variant of DNA polymerase δ (Pol δ). Sequencing of 16 genomes identified 1,206-bp substitutions generated over 33 generations by L612M Pol δ in a mismatch repair defective strain. Alignment of sequences flanking...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20876092
DOI: 10.1073/pnas.1010178107
PMCID: PMC2955150

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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