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Article

MutLα suppresses error-prone DNA mismatch repair and preferentially protects noncoding DNA from mutations.

The Journal of biological chemistry - 1 Jun 2024

Kadyrova Lyudmila Y, Mieczkowski Piotr A, Kadyrov Farid A

Abstract excerpt

The DNA mismatch repair (MMR) system promotes genome stability and protects humans from certain types of cancer. Its primary function is the correction of DNA polymerase errors. MutLα is an important eukaryotic MMR factor. We have examined the contributions of MutLα to maintaining genome stability. We show here that loss of MutLα in yeast increases the genome-wide mutation rate by ∼130-fold and generates a...

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Identifiers

PMID: 38782208
DOI: 10.1016/j.jbc.2024.107406
PMCID: PMC11231602

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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