Article
Trajectory and uniqueness of mutational signatures in yeast mutators.
Proceedings of the National Academy of Sciences of the United States of America - 6 Oct 2020
Loeillet Sophie, Herzog Mareike, Puddu Fabio, Legoix Patricia, Baulande Sylvain, Jackson Stephen P, Nicolas Alain G
Abstract excerpt
The acquisition of mutations plays critical roles in adaptation, evolution, senescence, and tumorigenesis. Massive genome sequencing has allowed extraction of specific features of many mutational landscapes but it remains difficult to retrospectively determine the mechanistic origin(s), selective forces, and trajectories of transient or persistent mutations and genome rearrangements. Here, we conducted a...
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