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Article

Mutator suppression and escape from replication error-induced extinction in yeast.

PLoS genetics - 1 Oct 2011

Herr Alan J, Ogawa Masanori, Lawrence Nicole A, Williams Lindsey N, Eggington Julie M, Singh Mallika, Smith Robert A, Preston Bradley D

Abstract excerpt

Cells rely on a network of conserved pathways to govern DNA replication fidelity. Loss of polymerase proofreading or mismatch repair elevates spontaneous mutation and facilitates cellular adaptation. However, double mutants are inviable, suggesting that extreme mutation rates exceed an error threshold. Here we combine alleles that affect DNA polymerase δ (Pol δ) proofreading and mismatch repair to define the...

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Identifiers

PMID: 22022273
DOI: 10.1371/journal.pgen.1002282
PMCID: PMC3188538

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Source receipt: pubmed, retrieved 7 Sept 2026.

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