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Article

Intronic enhancers of the human SNCA gene predominantly regulate its expression in brain in vivo.

Science advances - 25 Nov 2022

Cheng Fubo, Zheng Wenxu, Liu Chang, Barbuti Peter Antony, Yu-Taeger Libo, Casadei Nicolas, Huebener-Schmid Jeannette, Admard Jakob, Boldt Karsten, Junger Katrin, Ueffing Marius, Houlden Henry, Sharma Manu, Kruger Rejko, Grundmann-Hauser Kathrin, Ott Thomas, Riess Olaf

Abstract excerpt

Evidence from patients with Parkinson's disease (PD) and our previously reported α-synuclein (SNCA) transgenic rat model support the idea that increased SNCA protein is a substantial risk factor of PD pathogenesis. However, little is known about the transcription control of the human SNCA gene in the brain in vivo. Here, we identified that the DYT6 gene product THAP1 (THAP domain-containing apoptosis-associated...

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Identifiers

PMID: 36417521
DOI: 10.1126/sciadv.abq6324
PMCID: PMC9683720

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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