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Article

A cytosine-thymine (CT)-rich haplotype in intron 4 of SNCA confers risk for Lewy body pathology in Alzheimer's disease and affects SNCA expression.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Oct 2015

Lutz Michael W, Saul Robert, Linnertz Colton, Glenn Omolara-Chinue, Roses Allen D, Chiba-Falek Ornit

Abstract excerpt

INTRODUCTION: We recently showed that tagging single-nucleotide polymorphisms across the SNCA locus were significantly associated with increased risk for Lewy body (LB) pathology in Alzheimer's disease (AD) cases. However, the actual genetic variant(s) that underlie the observed associations remain elusive. METHODS: We used a bioinformatics algorithm to catalog structural variants in a region of SNCA intron 4,...

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Identifiers

PMID: 26079410
DOI: 10.1016/j.jalz.2015.05.011
PMCID: PMC4630109

Genes

SNCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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