Article
Alpha synuclein (SNCA) rs7684318 variant contributes to Parkinson's disease risk by altering transcription factor binding related with Notch and Wnt signaling.
Neuroscience letters - 17 Apr 2021
Naushad Shaik Mohammad, Hussain Tajamul, Alrokayan Salman, Kutala Vijay Kumar
Abstract excerpt
In view of inconsistencies in the association studies of alpha synuclein (SNCA) rs7684318 (chr4: 90655003 T > C) with Parkinson's disease (PD), we conducted a meta-analysis to establish the association of this variant with PD and examined changes in transcription factor binding. SNCA rs7684318 C-allele was identified as genetic risk factor for PD in fixed (OR: 1.53, 95 % CI: 1.40-1.68, p < 0.0001) and random...
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