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Article

Functional dissection of the α‐synuclein promoter: transcriptional regulation by ZSCAN21 and ZNF219

22 Jun 2009

Abstract excerpt

Alpha-synuclein (SNCA) is an abundant neuronal protein involved in synaptic neurotransmission. SNCA expression levels have been strongly implicated in Parkinson's disease pathogenesis. We have previously demonstrated that in the PC12 cell line elements in intron 1 may mediate SNCA transcriptional regulation in response to neurotrophins. We have now identified transcription factor (TF) binding sites in intron 1...

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PMID: 19549071
DOI: 10.1111/j.1471-4159.2009.06250.x

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