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Article

Discovering the 3' UTR-mediated regulation of alpha-synuclein.

Nucleic acids research - 15 Dec 2017

Marchese Domenica, Botta-Orfila Teresa, Cirillo Davide, Rodriguez Juan Antonio, Livi Carmen Maria, Fernández-Santiago Rubén, Ezquerra Mario, Martí Maria J, Bechara Elias, Tartaglia Gian Gaetano

Abstract excerpt

Recent evidence indicates a link between Parkinson's Disease (PD) and the expression of a-synuclein (SNCA) isoforms with different 3' untranslated regions (3'UTRs). Yet, the post-transcriptional mechanisms regulating SNCA expression are unknown. Using a large-scale in vitro /in silico screening we identified RNA-binding proteins (RBPs) that interact with SNCA 3' UTRs. We identified two RBPs, ELAVL1 and TIAR, that...

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Identifiers

PMID: 29149290
DOI: 10.1093/nar/gkx1048
PMCID: PMC5728410

Genes

SNCA
ELAVL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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