Article
HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis
22 Nov 2022
Abstract excerpt
Carbohydrate response element-binding protein (ChREBP) is a carbohydrate-sensing transcription factor that regulates both adaptive and maladaptive genomic responses in coordination of systemic fuel homeostasis. Genetic variants in the ChREBP locus associate with diverse metabolic traits in humans, including circulating lipids. To identify novel ChREBP-regulated hepatokines that contribute to its systemic...
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