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Article

Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling.

Endocrinology - 1 Apr 2014

Gattu Arijeet K, Birkenfeld Andreas L, Iwakiri Yasuko, Jay Steven, Saltzman Mark, Doll Jennifer, Protiva Petr, Samuel Varman T, Crawford Susan E, Chung Chuhan

Abstract excerpt

Pigment epithelium-derived factor (PEDF) is an antiinflammatory protein that circulates at high levels in the metabolic syndrome. Metabolic studies of PEDF knockout (KO) mice were conducted to investigate the relationship between PEDF, inflammatory markers, and metabolic homeostasis. Male PEDF KO mice demonstrated a phenotype consisting of increased adiposity, glucose intolerance, and elevated serum levels of...

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Identifiers

PMID: 24456163
DOI: 10.1210/en.2013-1785
PMCID: PMC5393334

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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