Article
Identification and function of phosphorylation in the glucose-regulated transcription factor ChREBP.
The Biochemical journal - 15 Apr 2008
Tsatsos Nikolas G, Davies Michael N, O'Callaghan Brennon L, Towle Howard C
Abstract excerpt
In the liver, induction of genes encoding enzymes involved in de novo lipogenesis occurs in response to increased glucose metabolism. ChREBP (carbohydrate-response-element-binding protein) is a basic helix-loop-helix/leucine zipper transcription factor that regulates expression of these genes. To evaluate the potential role of ChREBP phosphorylation in its regulation, we used MS to identify modified residues. In...
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