Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased AR expression in castration-resistant prostate cancer rapidly induces AR signaling reprogramming with the collaboration of EZH2

3 Nov 2022

Abstract excerpt

Elevated androgen receptor (AR) expression is a hallmark of castration-resistant prostate cancer (CRPC) and contributes to the restoration of AR signaling under the conditions of androgen deprivation. However, whether overexpressed AR alone with the stimulation of castrate levels of androgens can be sufficient to induce the reprogramming of AR signaling for the adaptation of prostate cancer (PCa) cells remains...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to PARP inhibition in cancer therapy
Share to Prostate Cancer Treatment and Research
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36408179
DOI: 10.3389/fonc.2022.1021845

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased AR expression in castration-resistant prostate cancer rapidly induces AR signaling reprogramming with the collaboration of EZH2PMID 36408179Read ↗

The epigenetic function of androgen receptor in prostate cancer progressionSemantic proximity Read ↗

Transcriptional repression by androgen receptor: roles in castration-resistant prostate cancerSemantic proximity Read ↗

The androgen receptor malignancy shift in prostate cancerSemantic proximity Read ↗

Epigenome-wide impact of MAT2A sustains the androgen-indifferent state and confers synthetic vulnerability in ERG fusion-positive prostate cancerSemantic proximity Read ↗

Shaping Chromatin States in Prostate Cancer by Pioneer Transcription FactorsSemantic proximity Read ↗

Androgen deprivation restores ARHGEF2 to promote neuroendocrine differentiation of prostate cancerSemantic proximity Read ↗

Epigenetic Reprogramming with Antisense Oligonucleotides Enhances the Effectiveness of Androgen Receptor Inhibition in Castration-Resistant Prostate CancerSemantic proximity Read ↗

Androgen Receptor Reprogramming Demarcates Prognostic Gene Sets In Prostate CancerSemantic proximity Read ↗

Androgen receptor (AR) heterogeneity in prostate cancer and therapy resistanceSemantic proximity Read ↗

Lineage plasticity and treatment resistance in prostate cancer: the intersection of genetics, epigenetics, and evolutionSemantic proximity Read ↗

Elevated levels of FOXA1 facilitate androgen receptor chromatin binding resulting in a CRPC-like phenotype.Semantic proximity Read ↗

Landscape of Allele-Specific Expression in Prostate Cancer Reveals Recurrent, Stage-Specific Events in AR Signaling and Resistance Pathways.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.