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Landscape of Allele-Specific Expression in Prostate Cancer Reveals Recurrent, Stage-Specific Events in AR Signaling and Resistance Pathways.

Molecular cancer research : MCR - 2 Apr 2026

Tsui Margaret, Hu Kevin, Song Hanbing, Hsu Sarah C, Chen Yih-An, Nuniz Lorraine, Pham Julia H, Chang Chih-Hao, Hui Keliana S F, Quigley David A, Li Jingjing, Huang Franklin W

Abstract excerpt

The effects of cis-regulatory alterations in prostate cancer are insufficiently characterized, presenting an opportunity to discover driver genes and therapeutic targets. To comprehensively study these effects, we identify genes undergoing allele-specific expression (ASE) in localized prostate cancer and metastatic castration-resistant prostate cancer (mCRPC) samples. By defining recurrent ASE events across...

Topics

Humans
Male
Signal Transduction
Gene Expression Regulation, Neoplastic
Alleles
Prostatic Neoplasms
Receptors, Androgen
Prostatic Neoplasms, Castration-Resistant
Neoplasm Staging

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41543497
DOI: 10.1158/1541-7786.MCR-25-0754
PMCID: PMC13007663

Genes

AR
ACSM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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