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Article

The androgen receptor malignancy shift in prostate cancer

23 Feb 2018

Abstract excerpt

BACKGROUND: Androgens and the androgen receptor (AR) are necessary for the development, function, and homeostatic growth regulation of the prostate gland. However, once prostate cells are transformed, the AR is necessary for the proliferation and survival of the malignant cells. This change in AR function appears to occur in nearly every prostate cancer. We have termed this the AR malignancy shift. METHODS: In...

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Share to Estrogen and related hormone effects
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PMID: 29473182
DOI: 10.1002/pros.23497

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