Article

Androgen Receptor Reprogramming Demarcates Prognostic Gene Sets In Prostate Cancer

2022-02-22

Abstract excerpt

The androgen receptor (AR) is a prostate master transcription factor. It binds to genetic enhancers, where it regulates gene activity and plays a fundamental role in prostate pathophysiology. Previous work has demonstrated AR-DNA binding is systematically and consistently reprogrammed during prostate tumorigenesis and disease progression. We charted these reprogrammed AR sites and identified genes proximal to them...

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Literature Corpus work: d076211b-d4f6-5bc3-bb38-0ff81e777325
DOI: 10.21203/rs.3.rs-1374790/v1

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