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Article

Androgen receptor (AR) heterogeneity in prostate cancer and therapy resistance

9 Jun 2021

Abstract excerpt

Androgen receptor (AR), a ligand-dependent nuclear transcription factor and a member of steroid hormone receptor family, plays an important role in prostate organogenesis by regulating epithelial differentiation and restricting cell proliferation. Although rarely mutated or amplified in treatment-naïve prostate cancer (PCa), AR signaling drives tumor growth and as a result, therapies that aim to inhibit AR...

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Share to Cancer, Lipids, and Metabolism
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Identifiers

PMID: 34118355
DOI: 10.1016/j.canlet.2021.06.006

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