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Article

Transcriptional repression by androgen receptor: roles in castration-resistant prostate cancer

1 Jan 2019

Abstract excerpt

Androgen receptor (AR), a hormonal transcription factor, plays important roles during prostate cancer progression and is a key target for therapeutic interventions. While androgen-deprivation therapies are initially successful in regressing prostate tumors, the disease ultimately comes back as castration-resistant prostate cancer (CRPC) or at the late stage as neuroendocrine prostate cancer (NEPC). CRPC remains...

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Share to Cancer, Lipids, and Metabolism
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PMID: 30950412
DOI: 10.4103/aja.aja_19_19

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