Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lineage plasticity and treatment resistance in prostate cancer: the intersection of genetics, epigenetics, and evolution

30 Jun 2023

Abstract excerpt

Androgen deprivation therapy is a cornerstone of treatment for advanced prostate cancer, and the development of castrate-resistant prostate cancer (CRPC) is the primary cause of prostate cancer-related mortality. While CRPC typically develops through a gain in androgen receptor (AR) signaling, a subset of CRPC will lose reliance on the AR. This process involves genetic, epigenetic, and hormonal changes that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Prostate Cancer Diagnosis and Treatment
Share to Prostate Cancer Treatment and Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37455903
DOI: 10.3389/fendo.2023.1191311

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lineage plasticity and treatment resistance in prostate cancer: the intersection of genetics, epigenetics, and evolutionPMID 37455903Read ↗

The Role of Epigenetic Change in Therapy-Induced Neuroendocrine Prostate Cancer Lineage PlasticitySemantic proximity Read ↗

Transcriptional and epigenetic reprogramming, lineage plasticity and therapy resistance in prostate cancerSemantic proximity Read ↗

Phenotypic Plasticity - Alternate Transcriptional Programs Driving Treatment Resistant Prostate CancerSemantic proximity Read ↗

Cellular plasticity and the neuroendocrine phenotype in prostate cancer.Semantic proximity Read ↗

Epigenetic mechanisms underlying subtype heterogeneity and tumor recurrence in prostate cancerSemantic proximity Read ↗

The epigenetic and transcriptional landscape of neuroendocrine prostate cancerSemantic proximity Read ↗

The heterogeneity of prostate cancers lacking AR activity will require diverse treatment approachesSemantic proximity Read ↗

Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance.Semantic proximity Read ↗

Molecular model for neuroendocrine prostate cancer progressionSemantic proximity Read ↗

Therapeutic Exploitation of Neuroendocrine Transdifferentiation Drivers in Prostate CancerSemantic proximity Read ↗

Therapy considerations in neuroendocrine prostate cancer: what next?Semantic proximity Read ↗

Aggressive variants of prostate cancer: underlying mechanisms of neuroendocrine transdifferentiationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.