Article

Androgen deprivation restores ARHGEF2 to promote neuroendocrine differentiation of prostate cancer

2022-06-22

Abstract excerpt

<title>Abstract</title> <p>Androgen receptor (AR) plays an important role in the progression of prostate cancer and has been targeted by castration or AR-antagonists. The emergence of castration-resistant prostate cancer (CRPC) after androgen deprivation therapy (ADT) is inevitable. However, it is not entirely clear how ADT fails or how it causes resistance. Through analysis of RNA-seq data, we nominate ARHGEF2 a...

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Literature Corpus work: 8fe5eb2f-dcda-5a40-9710-ba9ba5fc531f
DOI: 10.21203/rs.3.rs-1738099/v1

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