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Article

Elevated levels of FOXA1 facilitate androgen receptor chromatin binding resulting in a CRPC-like phenotype.

Oncogene - 11 Dec 2014

Robinson J L L, Hickey T E, Warren A Y, Vowler S L, Carroll T, Lamb A D, Papoutsoglou N, Neal D E, Tilley W D, Carroll J S

Abstract excerpt

Castration-resistant prostate cancer (CRPC) continues to pose a significant clinical challenge with new generation second-line hormonal therapies affording limited improvement in disease outcome. As the androgen receptor (AR) remains a critical driver in CRPC, understanding the determinants of its transcriptional activity is important for developing new AR-targeted therapies. FOXA1 is a key component of the AR...

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Share to Cell Proliferation
Share to Chromatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Hepatocyte Nuclear Factor 3-alpha

Share to Microarray Analysis

Share to Prostatic Neoplasms, Castration-Resistant

Share to Receptors, Androgen

Share to Up-Regulation

Source

Open in PubMed Open full text

Identifiers

PMID: 24292680
DOI: 10.1038/onc.2013.508
PMCID: PMC4051595

Genes

FOXA1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Elevated levels of FOXA1 facilitate androgen receptor chromatin binding resulting in a CRPC-like phenotype.PMID 24292680Read ↗

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