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Article

Shaping Chromatin States in Prostate Cancer by Pioneer Transcription Factors

24 Feb 2020

Abstract excerpt

The androgen receptor (AR) is a critical therapeutic target in prostate cancer that responds to antagonists in primary disease, but inevitably becomes reactivated, signaling onset of the lethal castration-resistant prostate cancer (CRPC) stage. Epigenomic investigation of the chromatin environment and interacting partners required for AR transcriptional activity has uncovered three pioneer factors that open up...

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PMID: 32094298
DOI: 10.1158/0008-5472.can-19-3447

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