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Article

Structural effects of spike protein D614G mutation in SARS-CoV-2.

Biophysical journal - 25 Jul 2023

Dokainish Hisham M, Sugita Yuji

Abstract excerpt

A single mutation from aspartate to glycine at position 614 has dominated all circulating variants of the severe acute respiratory syndrome coronavirus 2. D614G mutation induces structural changes in the spike (S) protein that strengthen the virus infectivity. Here, we use molecular dynamics simulations to dissect the effects of mutation and 630-loop rigidification on S-protein structure. The introduction of the...

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Source

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Identifiers

PMID: 36397671
DOI: 10.1016/j.bpj.2022.11.025
PMCID: PMC9671695

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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