Article
Cryo-EM structure of the SARS-CoV-2 Omicron spike.
Cell reports - 1 Mar 2022
Cerutti Gabriele, Guo Yicheng, Liu Lihong, Liu Liyuan, Zhang Zhening, Luo Yang, Huang Yiming, Wang Harris H, Ho David D, Sheng Zizhang, Shapiro Lawrence
Abstract excerpt
The recently reported B.1.1.529 Omicron variant of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) includes 34 mutations in the spike protein relative to the Wuhan strain, including 15 mutations in the receptor-binding domain (RBD). Functional studies have shown Omicron to substantially escape the activity of many SARS-CoV-2-neutralizing antibodies. Here, we report a 3.1 Å-resolution cryoelectron...
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