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D614G Mutation Alters SARS-CoV-2 Spike Conformation and Enhances Protease Cleavage at the S1/S2 Junction.

Cell reports - 12 Jan 2021

Gobeil Sophie M-C, Janowska Katarzyna, McDowell Shana, Mansouri Katayoun, Parks Robert, Manne Kartik, Stalls Victoria, Kopp Megan F, Henderson Rory, Edwards Robert J, Haynes Barton F, Acharya Priyamvada

Abstract excerpt

The severe acute respiratory coronavirus 2 (SARS-CoV-2) spike (S) protein is the target of vaccine design efforts to end the coronavirus disease 2019 (COVID-19) pandemic. Despite a low mutation rate, isolates with the D614G substitution in the S protein appeared early during the pandemic and are now the dominant form worldwide. Here, we explore S conformational changes and the effects of the D614G mutation on a...

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Protein Structure, Quaternary
Cryoelectron Microscopy
Immunogenicity, Vaccine
Peptide Hydrolases
Protein Domains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Stability

Spike Glycoprotein, Coronavirus

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Identifiers

PMID: 33417835
DOI: 10.1016/j.celrep.2020.108630
PMCID: PMC7762703

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