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Article

Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity.

Science (New York, N.Y.) - 6 Aug 2021

Gobeil Sophie M-C, Janowska Katarzyna, McDowell Shana, Mansouri Katayoun, Parks Robert, Stalls Victoria, Kopp Megan F, Manne Kartik, Li Dapeng, Wiehe Kevin, Saunders Kevin O, Edwards Robert J, Korber Bette, Haynes Barton F, Henderson Rory, Acharya Priyamvada

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with multiple spike mutations enable increased transmission and antibody resistance. We combined cryo-electron microscopy (cryo-EM), binding, and computational analyses to study variant spikes, including one that was involved in transmission between minks and humans, and others that originated and spread in human populations. All variants...

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Share to Angiotensin-Converting Enzyme 2
Share to Antibodies, Neutralizing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antigens, Viral

Share to Cryoelectron Microscopy

Share to Immune Evasion

Share to Protein Structure, Quaternary

Share to Spike Glycoprotein, Coronavirus

Source

Open in PubMed Open full text

Identifiers

PMID: 34168071
DOI: 10.1126/science.abi6226
PMCID: PMC8611377

Genes

ACE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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