Article

Impacts on the structure-function relationship of SARS-CoV-2 spike by B.1.1.7 mutations

2021-05-12

Abstract excerpt

The UK variant of the severe acute respiratory syndrome coronavirus (SARS-CoV-2), known as B.1.1.7, harbors several point mutations and deletions on the spike (s) protein, which potentially alter its structural epitopes to evade host immunity while enhancing host receptor binding. Here we report the cryo-EM structures of the S protein of B.1.1.7 in its apo form and in the receptor ACE2-bound form. One or two of th...

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Literature Corpus work: cbfe3c43-f503-5a60-94bb-0d3ba32e64f2
DOI: 10.1101/2021.05.11.443686

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