Article

Structural and Conformational Impact of Deleterious Spike Protein Mutations in SARS-CoV-2 Omicron Lineages

2025-02-27

Abstract excerpt

<h4>Background</h4> A large number of mutations in the Spike (S) protein of the SARS-CoV-2 omicron variant have been noted to alter the receptor binding domain (RBD) and increase the binding surface and enhance the opening of the binding pocket. The cumulative effect of S1 and S2 subunit mutations can influence the conformational dynamics of the binding surface, facilitating the release of viral genome into host...

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Literature Corpus work: 9010f03d-c02c-5633-8bb1-38f9095b7972
DOI: 10.1101/2025.02.25.639252

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