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Conformational and Stability Analysis of SARS-CoV-2 Spike Protein Variants by Molecular Simulation

12 Mar 2025

Abstract excerpt

We performed a comprehensive structural analysis of the conformational space of several spike (S) protein variants using molecular dynamics (MD) simulations. Specifically, we examined four well-known variants (Delta, BA.1, XBB.1.5, and JN.1) alongside the wild-type (WT) form of SARS-CoV-2. The conformational states of each variant were characterized by analyzing their distributions within a selected space of...

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PMID: 40137759
DOI: 10.3390/pathogens14030274

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