Article

Structural Ramifications of Spike Protein D614G Mutation in SARS-CoV-2

2022-01-25

Abstract excerpt

A single mutation from aspartate to glycine at position 614 has dominated all circulating variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). D614G mutation induces structural changes in the Spike (S) protein that strengthen the virus infectivity. Here, we use molecular dynamics simulations to dissect the effects of mutation and 630-loop rigidification on wild-type structure. The introduc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: adfd85af-5d0e-500a-b9c5-0239129fb8ec
DOI: 10.1101/2022.01.24.477651

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structural Ramifications of Spike Protein D614G Mutation in SARS-CoV-2DOI 10.1101/2022.01.24.477651Read

Structural effects of spike protein D614G mutation in SARS-CoV-2.Semantic proximity Read

Structural impact on SARS-CoV-2 spike protein by D614G substitutionSemantic proximity Read

Structural impact on SARS-CoV-2 spike protein by D614G substitutionSemantic proximity Read

Insight into molecular characteristics of SARS-CoV-2 spike protein following D614G point mutation, a molecular dynamics study.Semantic proximity Read

Structural Analysis And Molecular Characteristics of SARSCoV-2 Spike Protein Following S494P Point Mutation: Molecular Dynamics StudySemantic proximity Read

The inherent flexibility of receptor binding domains in SARS-CoV-2 spike proteinSemantic proximity Read

Structural and Conformational Impact of Deleterious Spike Protein Mutations in SARS-CoV-2 Omicron LineagesSemantic proximity Read

D936Y and Other Mutations in the Fusion Core of the SARS-CoV-2 Spike Protein Heptad Repeat 1: Frequency, Geographical Distribution, and Structural EffectSemantic proximity Read

Study on Sequence Mutation and Molecular Dynamics Simulation of D614G SARS-CoV-2 Spike Protein in IndonesiaSemantic proximity Read

Unraveling the stability landscape of mutations in the SARS-CoV-2 receptor-binding domain.Semantic proximity Read

A Comprehensive Analysis of Structural and Functional Changes Induced by SARS-CoV-2 Spike Protein MutationsSemantic proximity Read

Impacts on the structure-function relationship of SARS-CoV-2 spike by B.1.1.7 mutationsSemantic proximity Read