Article
Mitochondrial DNA copy number changes, heteroplasmy, and mutations in plasma-derived exosomes and brain tissue of glioblastoma patients.
Molecular and cellular probes - 1 Dec 2022
Soltész Beáta, Pös Ondrej, Wlachovska Zuzana, Budis Jaroslav, Hekel Rastislav, Strieskova Lucia, Liptak Jana Bozenka, Krampl Werner, Styk Jakub, Németh Nikolett, Keserű Judit Sz, Jenei Adrienn, Buglyó Gergely, Klekner Álmos, Nagy Bálint, Szemes Tomas
Abstract excerpt
Glioblastoma is the most common malignant tumor of the central nervous system (CNS) in adults. Glioblastoma cells show increased glucose consumption associated with poor prognosis. Since mitochondria play a crucial role in energy metabolism, mutations and copy number changes of mitochondrial DNA may serve as biomarkers. As the brain is difficult to access, analysis of mitochondria directly from the brain tissue...
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