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Article

Assessment of circulating tumor DNA in cerebrospinal fluid by whole exome sequencing to detect genomic alterations of glioblastoma.

Chinese medical journal - 20 Jun 2020

Duan Hao, Hu Ji-Long, Chen Zheng-He, Li Jue-Hui, He Zhen-Qiang, Wang Zhen-Ning, Zhang Guan-Hua, Guo Xiao-Yu, Liang Lun, Mou Yong-Gao

Abstract excerpt

BACKGROUND: Cerebrospinal fluid (CSF) has been demonstrated as a better source of circulating tumor DNA (ctDNA) than plasma for brain tumors. However, it is unclear whether whole exome sequencing (WES) is qualified for detection of ctDNA in CSF. The aim of this study was to determine if assessment of ctDNA in CSF by WES is a feasible approach to detect genomic alterations of glioblastoma. METHODS: CSFs of ten...

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Identifiers

PMID: 32558704
DOI: 10.1097/CM9.0000000000000843
PMCID: PMC7339330

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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