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Article

Somatic Mutations in Nuclear and Mitochondrial Genes of Mitochondrial Proteins in Primary and Recurrent Glioblastoma.

International journal of molecular sciences - 12 Feb 2026

Tompa Marton, Galik Bence, Urban Peter, Gyenesei Attila, Kalman Bernadette

Abstract excerpt

The accumulation of somatic mutations contributes to clonal evolution and biological properties of cancers. Acquired mutations in mitochondrial (mt)DNA have been studied, but with the exception of those in isocitrate dehydrogenase genes, no comprehensive assessment of mutations in nuclear mitochondrial genes has been reported in sequential glioblastoma (GBM). We obtained ten pairs of GBM samples at diagnosis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41751913
DOI: 10.3390/ijms27041773
PMCID: PMC12940986

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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