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Article

Mitochondrial DNA Alterations in Glioblastoma (GBM).

International journal of molecular sciences - 29 May 2021

Leão Barros Mariceli Baia, Pinheiro Danilo do Rosário, Borges Bárbara do Nascimento

Abstract excerpt

Glioblastoma (GBM) is an extremely aggressive tumor originating from neural stem cells of the central nervous system, which has high histopathological and genomic diversity. Mitochondria are cellular organelles associated with the regulation of cellular metabolism, redox signaling, energy generation, regulation of cell proliferation, and apoptosis. Accumulation of mutations in mitochondrial DNA (mtDNA) leads to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34072607
DOI: 10.3390/ijms22115855
PMCID: PMC8199454

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