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Mitochondrial DNA Alterations in Glioblastoma and Current Therapeutic Targets.

Frontiers in bioscience (Landmark edition) - 23 Oct 2024

Kurdi Maher, Bamaga Ahmed, Alkhotani Alaa, Alsharif Thamer, Abdel-Hamid Ghada A, Selim Mohamed E, Alsinani Taghreed, Albeshri Ahmed, Badahdah Adnan, Basheikh Mazen, Baeesa Saleh

Abstract excerpt

Metabolic reprogramming within tumor cells involves a shift towards either glycolysis or mitochondrial respiration, depending on the stage of tumor progression. Consequently, irreversible dysfunction of the mitochondria is considered a crucial mechanism driving the progression mechanism. While numerous mutations in mitochondrial DNA (mtDNA) have been identified across various tumor types, including glioblastoma,...

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PMID: 39473421
DOI: 10.31083/j.fbl2910367

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