Article
A comprehensive characterization of mitochondrial DNA mutations in glioblastoma multiforme.
The international journal of biochemistry & cell biology - 1 Jun 2015
Vidone Michele, Clima Rosanna, Santorsola Mariangela, Calabrese Claudia, Girolimetti Giulia, Kurelac Ivana, Amato Laura Benedetta, Iommarini Luisa, Trevisan Elisa, Leone Marco, Soffietti Riccardo, Morra Isabella, Faccani Giuliano, Attimonelli Marcella, Porcelli Anna Maria, Gasparre Giuseppe
Abstract excerpt
Glioblastoma multiforme (GBM) is the most malignant brain cancer in adults, with a poor prognosis, whose molecular stratification still represents a challenge in pathology and clinics. On the other hand, mitochondrial DNA (mtDNA) mutations have been found in most tumors as modifiers of the bioenergetics state, albeit in GBM a characterization of the mtDNA status is lacking to date. Here, a characterization of the...
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