Article
Identification and functional prediction of mitochondrial complex III and IV mutations associated with glioblastoma.
Neuro-oncology - 1 Jul 2015
Lloyd Rhiannon E, Keatley Kathleen, Littlewood D Timothy J, Meunier Brigitte, Holt William V, An Qian, Higgins Samantha C, Polyzoidis Stavros, Stephenson Katie F, Ashkan Keyoumars, Fillmore Helen L, Pilkington Geoffrey J, McGeehan John E
Abstract excerpt
BACKGROUND: Glioblastoma (GBM) is the most common primary brain tumor in adults, with a dismal prognosis. Treatment is hampered by GBM's unique biology, including differential cell response to therapy. Although several mitochondrial abnormalities have been identified, how mitochondrial DNA (mtDNA) mutations contribute to GBM biology and therapeutic response remains poorly described. We sought to determine the...
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