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ACE2 N-glycosylation modulates interactions with SARS-CoV-2 spike protein in a site-specific manner

5 Nov 2022

Abstract excerpt

SARS-CoV-2 has evolved continuously and accumulated spike mutations with each variant having a different binding for the cellular ACE2 receptor. It is not known whether the interactions between such mutated spikes and ACE2 glycans are conserved among different variant lineages. Here, we focused on three ACE2 glycosylation sites (53, 90 and 322) that are geometrically close to spike binding sites and investigated...

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PMID: 36335195
DOI: 10.1038/s42003-022-04170-6

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