Article

Virus-Receptor Interactions of Glycosylated SARS-CoV-2 Spike and Human ACE2 Receptor

2020-06-26

Abstract excerpt

<h4>SUMMARY</h4> The current COVID-19 pandemic is caused by the SARS-CoV-2 betacoronavirus, which utilizes its highly glycosylated trimeric Spike protein to bind to the cell surface receptor ACE2 glycoprotein and facilitate host cell entry. We utilized glycomics-informed glycoproteomics to characterize site-specific microheterogeneity of glycosylation for a recombinant trimer Spike mimetic immunogen and for a sol...

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Literature Corpus work: 9f75fac8-33be-5b1b-9983-296cb6dbd1af
DOI: 10.1101/2020.06.25.172403

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