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Article

Role of N-linked glycosylation sites in human ACE2 in SARS-CoV-2 and hCoV-NL63 infection.

Journal of virology - 20 May 2025

Noettger Sabrina, Zech Fabian, Nchioua Rayhane, Pastorio Chiara, Jung Christoph, Jacob Timo, Stenger Steffen, Kirchhoff Frank

Abstract excerpt

Angiotensin-converting enzyme 2 (ACE2) is a transmembrane protein known for its physiological role in the renin-angiotensin system that also serves as a receptor for entry of SARS-CoV-1, SARS-CoV-2, and the seasonal human coronavirus NL63 (hCoV-NL63). ACE2 contains seven N-linked glycosylation sites. Molecular simulation and binding analyses suggest that some of them are involved in the interaction with the Spike...

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Share to Angiotensin-Converting Enzyme 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycosylation

Share to Peptidyl-Dipeptidase A

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Source

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Identifiers

PMID: 40152594
DOI: 10.1128/jvi.02202-24
PMCID: PMC12090729

Genes

ACE2
TMPRSS2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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